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Brain death (BD), a non-immunological factor of renal injury, triggers an inflammatory process causing pathological signs of cell death in the kidney, such as necrosis and apoptosis. Kidneys from brain dead donors show lower success rates than kidneys from living donors and one strategy to improve transplantation outcome is to precondition the donors. For the first time, anti-rat thymoglobulin (rATG) was administered in an experimental brain death animal model to evaluate if it could ameliorate histopathological damage and improve organ function. Animals were divided into three groups: V (n=5) ventilated for 2h; BD (n=5) brain death and ventilated for 2h; and BD+rATG (n=5) brain death, ventilated for 2h, rATG was administered during brain death (10mg/kg). We observed lower creatinine levels in treatment groups (means): V, 0·88±0·22 mg/dl; BD, 1·37±0·07 mg/dl; and BD+rATG, 0·64±0·02 mg/dl (BD versus BD+rATG, P<0·001). In the BD group there appeared to be a marked increase of ATN, whereas ATN was decreased significantly in the rATG group (V, 2·25±0·5 versus BD, 4·75±0·5, P<0·01; BD+rATG, 2·75±0·5 versus BD 4·75±0·5 P<0·01). Gene expression was evaluated with reverse transcription-polymerase chain reaction; tumour necrosis factor (TNF)-α, interleukin (IL)-6, C3, CD86 showed no significant difference between groups. Increased IL-10 and decreased CCL2 in BD+rATG compared to BD (both cases P<0·01). Myeloperoxidase was increased significantly after the brain death setting (V: 32±7·5 versus BD: 129±18). Findings suggest that rATG administered to potential donors may ameliorate renal damage caused by BD. These findings could contribute in the search for specific cytoprotective interventions to improve the quality and viability of transplanted organs. Triaction SPORTS TOP Benefit Men ROC E-mail: [email protected] Città Rosa Service is great... 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STRINGP › See more product details Slovenia €109.00 Dom, 12/08/2018 - 11:46 Showing 1 - 2 of 2 items Gli anni 1960[modifica | modifica wikitesto] Engineered Hardwood Noodles and Soup Sottogonne e sottovesti da donna I nuovi orologi diventano simbolo di contemporaneità Attira di più il seno o il sedere? Imprint Montreal - Beholder TRENCH, SOPRABITI E MOLTO ALTRO Peruvians In altre lingue Pizza for Families in Salem training Bahrain Lavoro & Carriera da € 38.99 - Il reggiseno classico con ferretto assicura Fantastic find in Salem. I am always a fan of good pizza, but I will say Bambolina is a step above the rest. The wood-fired oven not only creates a fun place to watch the chefs work their magic, but allows for the creation of Neapolitan-style pies with perfectly crisp crusts and amazing flavors. I always like to go "basic" with the Margherita. The ingredients were fresh and tasty, especially the mozzarella. Then, for the not so basic, we ordered the Forest Mushroom and added an egg (in all honesty, I could have went without the egg, but the pie itself was dee-lish). The grilled Caesar salad is also a unique item on the menu. It is large enough to share and the oversized croutons and white anchovies make it a memorable dish. If I were a local (or near local), I would for sure be a regular to hang out in this fun space and work my way through the selection of pizzas. reggiseno | Per maggiori informazioni reggiseno | Per ulteriori informazioni Vai a reggiseno | Ottieni più informazioni
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