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Our objective was to study the impact of immunosuppressive treatment (IS) on IRI applying only one dose of IS before orthotopic kidney autotransplantation. Twenty-four rats allocated in four groups were studied. One group served as control (G1: autotransplanted rats without IS) and the rest received IS 12 h before kidney autotransplantation (G2: Rapamycin, G3: Mycophenolate mofetil and G4: Tacrolimus). Improved renal function and systemic inflammatory response were found among IS groups compared to the control group (Delta Urea p<0.0001; Delta Creatinine p<0.0001; Delta C3 p<0.001). The number of apoptotic nuclei in renal medulla in G1 was higher than in IS groups (p<0.0001). Tubular damage was less severe in IS groups respecting G1 (p<0.001). C3, TNF-α and IL-6 expression in kidney samples was reduced when IS was used compared to the control group. No differences were observed among the different immunosuppressive drugs tested. However, Heme oxygenase-1(HO-1) was increased only in Rapamycin treatment. These data suggest that the use of IS administered before transplant attenuates the IRI process after kidney transplantation in an animal model. SCARICA L’APP STATP Pro Kennex "" EU 37 US - 6.5 The team behind Bambolina in Salem will open a new restaurant, Kokeshi, nearby, serving up "Asian-inspired street food." Owners Tim Haigh and Larry Leibowitz are aiming for a winter opening for their noodle-filled new project, which will feature their spin on ramen and more. No strangers to carbs, the two serve up excellent wood-fired pizza ("neo-Neapolitan," they call it), pasta, and more at Bambolina, which celebrated its first anniversary in June. Plus, they’ve just announced plans to host a regular Montreal-style bagel pop-up at Bambolina; more on that below. g stringa | Scopri di più qui g stringa | Scopri di più qui su g stringa | Scopri di più qui Traducao
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